![]() ![]() Comparative developmental studies in ascidians with divergent genomes will thus uncover shared ascidian strategies, and contribute to a better understanding of the diversity of developmental strategies within chordates. Between ascidians and vertebrates, major fate determinants, such as Otx and Nodal, can be co-opted into different networks. ![]() Within ascidians, developmental regulatory networks are remarkably robust to genome sequence divergence. Our results thus highlight that the modes of gene regulatory network evolution differ with the evolutionary scale considered. Moreover, we found that this strategy is conserved in the distantly related ascidian Phallusia mammillata, in spite of extreme sequence divergence in the cis-regulatory sequences involved. We report that the combined action of two direct FGF targets, the TGFβ factor Nodal, acting via Smad- and Fox-binding sites, and the transcription factor Otx suffices to trigger ascidian posterior neural tissue formation. We combined molecular embryology and cis-regulatory analysis to unveil in the ascidian Ciona intestinalis the remarkably simple proximal genetic network that controls posterior neural fate acquisition downstream of FGF. ![]() In ascidians, FGF-mediated neural induction occurs at the 32-cell stage in two blastomere pairs, precursors respectively of anterior and posterior neural tissue. In chordates, neural induction is the first step of a complex developmental process through which ectodermal cells acquire a neural identity. ![]()
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